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. Author manuscript; available in PMC: 2015 Oct 9.
Published in final edited form as: Nanotoxicology. 2013 May 28;8(5):485–507. doi: 10.3109/17435390.2013.801089

Figure 3.

Figure 3

Subchronic exposure (6 months) to dispersed SWCNTs, MWCNTs and asbestos results in neoplastic-like transformation of SAECs compared to DISP control cells. A-1) Increased WST-1 proliferation activity, A-2) trypan blue exclusion cell number and B) soft agar colony formation in D-SWCNTs, D-MWCNTs and ASB cells compared to control cells. C) D-SWNCT and D-MWCNT cells possessed significantly greater Matrigel invasion and Transwell migration ability in growth factor-free medium than control and ASB cells. D) Enhanced angiogenesis tube formation behaviour of HUVEC cells exposed to conditioned media from D-SWCNT, D-MWCNT, ASB and SAL cell lines. Parental SAECs (pSAEC) displayed significantly lower angiogenic ability than DIPS cells. Columns with error bars represent mean ± SE. Three or more independent experiments were performed for each assay. * indicate significant difference vs. non-treated control.