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. Author manuscript; available in PMC: 2015 Oct 9.
Published in final edited form as: Nature. 2005 Aug 11;436(7052):807–811. doi: 10.1038/nature03845

Figure 4. Impact of mutations in MYC on p53 tumour suppressor action and Bim induction in human Burkitt’s lymphomas.

Figure 4

a, Kaplan–Meier curve showing mouse survival after adoptive transfer with p53+/− HSCs infected with the indicated MYC retroviral constructs. Inset, Representative allele-specific PCR assay showing retention of the wild-type p53 allele in lymphomas produced by mutant but not wild-type MYC. b, Kaplan–Meier curve showing mouse survival after adoptive transfer with p53−/− HSCs infected as in a. Inset, western blot analysis of representative lymphomas harbouring the indicated MYC allele. c, Bim expression in DLBCL and wild-type MYC-expressing and mutant MYC-expressing Burkitt’s lymphomas as assessed by immunohistochemisty using an anti-Bim antibody. The frequency of Bim-positive tumours in each category is indicated.