Figure 4.

Fmr1 KO rats have normal spatial reference memory acquisition and reversal learning. (A) Fmr1 KO rats learn the hidden-platform version of the water maze similarly to WT littermates as measured by a decrease over days in the path taken to escape (A) and the number of crossings over the platform location on daily probe trials (B). Performance during reversal learning was comparable between genotypes as measured by path to escape (C) and the number of crossings over the old and new platform locations during probe trials (D). (E) Fmr1 KO rats swim faster than WT littermates over all days tested.