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. 2015 Aug 7;24(21):6093–6105. doi: 10.1093/hmg/ddv321

Figure 1.

Figure 1.

Anti-Aß4 scFvs suppress Aß42 neurotoxicity in the eye. (A–F) Fresh eyes and (G–L) scanning electron micrographs (SEM) of flies expressing LacZ or Aß42 constructs under the control of gmr-Gal4. Control flies expressing LacZ in all eye cells display highly organized eyes with hexagonal lenses (A and G). Flies co-expressing Aß42 and LacZ present small, depigmented and disorganized eyes with fused ommatidia and necrotic spots (B and H, arrow). Flies co-expressing Aß42 and scFv9 show larger and better-organized eyes, but fusions and disorganization are still evident (C and I). Flies co-expressing Aß42 and scFv42.2 show larger and slightly disorganized eyes, with fewer ommatidia fusions and holes (D and J). Flies co-expressing Aß42 with two copies of scFv9 show improved eye organization (E and K). Flies co-expressing Aß42 together with scFv9 and scFv42.2 display large eyes with improved organization and few ommatidia defects (F and L).