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. 2015 Aug 7;24(21):6093–6105. doi: 10.1093/hmg/ddv321

Figure 2.

Figure 2.

Anti-Aß scFvs suppress APPswe toxicity in the eye. (A–E) Fresh eyes and (F–O) SEM of flies expressing LacZ or APPswe BACE1 constructs under the control of gmr-Gal4. Control flies expressing LacZ in all eye cells display highly organized eyes with hexagonal ommatidia (A, F and K). Flies co-expressing APPswe BACE1 and LacZ present small, depigmented and disorganized eyes (B, G and L). Flies co-expressing APPswe BACE1 and scFv9 or scFv42.2 exhibit small, but better-organized eyes (C, D, H, I, M and N). Flies co-expressing APPswe BACE1 together with scFv9 and scFv42.2 show larger eyes with improved organization of ommatidia and fewer broken lenses (E, J and O). Arrows indicate fused ommatidia and arrowheads show broken lens surface.