Table 4.
Gene sets that correlate with immunization differences in mutant HD mice function in pro-inflammatory pathways
| Comparison | NFkB | Ag process | Cytokine signaling |
Macrophages |
||
|---|---|---|---|---|---|---|
| Pro-inflam | Anti-inflam | Pro-inflam | Anti-inflam | |||
| Imm R61 > R61 | ||||||
| Imm R61 < R61 | ||||||
| Imm zQ175 > zQ175 | ||||||
| Imm zQ175 > ImmWT | ||||||
| Imm R61 > Imm WT | ||||||
| Imm zQ175 < ImmWT | ||||||
| Imm R61 < Imm WT | ||||||
The fifteen gene sets (in Table 3) were organized into biologically functional groupings. Four functional groupings were identified. Shaded boxes represent affected pathways.