. 2015 Aug 24;24(21):6186–6197. doi: 10.1093/hmg/ddv335

Table 5.

Individual immune-related genes are differentially expressed after immunization of mutant HD and wild-type mice

Comparison	Innate immune responses		T/B cell responses
Comparison	Pro-inflammatory	Anti-inflammatory	T/B cell responses
Imm R61 > Imm WT	Tnf (cytokine)	Nfkbia (negative regulator NFkB)
Imm zQ175 > Imm WT	Tnf, Il1b, Il1rap, Il6, Ifng, Cxcl14, Ccrl2 (cytokine/chemokine/receptor) Tlr2 (Toll-like receptor) Arg2 (ROS production) Cd177 (neutrophil activation)	Nfkbia (negative regulator NFkB), Tnfaip3 (negative regulator TNF) I11rn (negative regulator IL1B) Cish (negative regulator JAK/STAT)
Imm R61 < Imm WT	Aif1 (macrophages) Nfatc2 (homeostasis)		Fcgr1 (phagocytic macrophages) Aif1 (CD4 T cells, Th2 cells) Nfatc2 (memory CD4, Th2 cells) Fyb (memory T cells) Lair1 (negative regulator T cell effector functions)
Imm zQ175 < Imm Wt	Aif1 (macrophages) Nfatc2 (homeostasis) Icam1 (extravasation)		Fcgr1 (phagocytic macrophages) Aif1 (CD4 T cells, Th2 cells) Nfatc2 (memory CD4, Th2 cells) Icam1 (memory CD8 T cells) Il4r (Th2 cells) H2-Q1 (Ag presentation/CD8 T cells)

Genes in the leading-edge subset from eight gene sets (in Table 3) for immunized mutant versus immunized wild-type comparisons were sorted based on function and assigned to two categories, innate immune responses or T/B cell responses.