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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Ann Epidemiol. 2015 Mar 21;25(7):519–525.e2. doi: 10.1016/j.annepidem.2015.03.008

Table 4.

Prevalence estimates applying additional criteria for inclusion and minimum enrollment

Prevalence definitiona
Disease ≥ 6 months
enrollment		 ≥ 12 months
enrollment		 ≥ mean enrollment of
source populationd 		≥ mean enrollment
of casesd 		Percent change in
estiamte
Drug
benefitb 		Users of
benefitc 		Drug
benefitb 		Users of
benefitc 		Drug
benefitb 		Users of
benefitc 		Drug
benefitb 		Users of
benefitc 		Drug
benefitb 		Users of
benefitc
Crohn’s disease Cases/100,000 155.8 173.9 173.2 186.6 199.6 213.9 214.9 221.8
n 85,454 111,511 76,660 100,080 58,241 64,016 41,730 52,237
Ulcerative
colitis		 Cases/100,000 140.1 157.0 159.9 172.8 195.7 213.3 220.5 228.1
n 76,877 100,660 70,762 92,717 57,106 63,833 40,863 51,335
EoE Cases/100,000 61.8 67.6 69.9 73.9 87.0 92.3 99.1 101.4
n 33,903 43,356 30,919 39,644 25,382 27,618 18,363 22,810
Barrett’s
esophagus		 Cases/100,000 131.2 151.8 153.2 171.1 194.9 217.1 225.2 237.0
n 71,966 97,353 67,794 91,777 56,880 64,960 39,893 52,322
Celiac disease Cases/100,000 58.6 66.5 67.0 73.3 83.6 91.2 94.2 98.8
n 32,172 42,622 29,648 39,342 24,395 27,306 17,139 22,239
Source
population		 n 54,858,366 64,132,756 44,264,058 53,643,840 29,182,094 29,924,646 Variablee Variablef
a

Definitions based on continuous enrollment for period specified for any enrollee meeting the enrollment definition specified during 2009–2012

b

Documentation of the enrollee having a prescription drug benefit as part of their health insurance plan

c

Documentation of the enrollee having at least 1 CPT, NDC, IDC-9, HCPCS code during the enrollment period specified

d

Definition for inclusion in source population based on individual having ≥ mean enrollment period of source population (622 days for drug benefit and 660 days for users of benefit) or cases (varies by disease condition as described in Table 2) within 2009–2012

e

Crohn’s disease – n=19,418,589; ulcerative colitis – n=18,534,133; EoE – n=18,534,831; Barrett’s esophagus – n= 17,718,307; celiac disease – n=18,187,751

f

Crohn’s disease – n=23,549,560; ulcerative colitis – n=22,508,811; EoE – n=22,504,132; Barrett’s esophagus – n= 22,074,561; celiac disease – n=22,499,335