Table 1.
Characteristics of PEG–PLA synthesized polymers
| Batch | Copolymer weight ratio MnPEG/MnPLAa | EG/LAb | GPC
|
DSC
|
CMC (mol/L) | |||
|---|---|---|---|---|---|---|---|---|
| Mn(kDa) | Mw(kDa) | Mw/Mn | Tm(°C) | ΔHm(J/g) | ||||
| 1 | 5000:3900 | 2.1 | 14.16 | 15.48 | 1.07 | 53.81 | −85.13 | 1.8 × 10−8 |
| 2 | 5000:5800 | 1.4 | 15.89 | 17.00 | 1.09 | 51.96 | −56.97 | 1.3 × 10−8 |
| 3 | 5000:7600 | 1.1 | 17.55 | 23.06 | 1.36 | 53.03 | −48.36 | 1.1 × 10−8 |
| 4 | 2000:3800 | 0.9 | 6.16 | 8.19 | 1.32 | 54.13 | −49.86 | 1.6 × 10−8 |
| 5 | 10000:3600 | 4.5 | 19.24 | 21.01 | 1.09 | 63.16 | −105.35 | 5.2 × 10−8 |
Notes:
a
Copolymer weight ratio of PEG and PLA calculated from 1H NMR;
b
molar ratio of PEG to PLA in the copolymers, calculated from 1H NMR spectra.
Abbreviations: PEG–PLA, poly(ethylene glycol)–poly(d,l-lactide); GPC, gel permeation chromatography; DSC, differential scanning calorimetry; EG/LA, Poly(ethylene glycol)/Poly(d,l-lactide); CMC, critical micelle concentration; 1H NMR, proton nuclear magnetic resonance.