Table 4.
Pharmacokinetic parameters of rhEPO in the Sprague– Dawley rats
| Parameters | AUC
|
T1/2
|
Cmax
|
Ratio* |
|---|---|---|---|---|
| μg/L · h | h | ng/mL | ||
| Native rhEPO | 15.96 ± 8.02 | 2.02 ± 0.59 | 12.07 ± 4.33 | 1.00 |
| PEG10000 –PLA3600 micelle | 23.01 ± 2.56 | 3.62 ± 0.09 | 16.65 ± 4.35 | 1.44 |
| PEG5000–PLA3900 micelle | 32.83 ± 3.87 | 4.36 ± 0.36 | 39.88 ± 8.76 | 2.00 |
| PEG2000–PLA3800micelle | 31.75 ± 6.53 | 4.12 ± 0.41 | 32.36 ± 3.89 | 1.99 |
Note:
*
Ratio = (AUC of rhEPO-loaded PEG–PLA micelles)/(AUC of native rhEPO).
Abbreviations: rhEPO, recombinant human erythropoietin; AUC, area under curve; T1/2, plasma half-life; PEG–PLA, poly(ethylene glycol)–poly(d,l-lactide).