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. 2015 Oct 5;10:6257–6276. doi: 10.2147/IJN.S92449

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© 2015 Gurunathan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of GO, rGO, rGO–Ag nanocomposite, and AgNPs on caspase-3 activity in human ovarian cancer cells.

Notes: Ovarian cancer cells were treated with GO, rGO, rGO–Ag nanocomposite, and AgNPs with or without the caspase-3 inhibitor Ac-DEVD-CHO for 24 hours. The concentration of p-nitroanilide released from the substrate was calculated from the absorbance at 405 nm. The results are expressed as the mean ± standard deviation of three separate experiments. The treated groups showed statistically significant differences from the control group by the Student’s t-test (*P<0.05).

Abbreviations: Con, control; GO, graphene oxide; rGO, reduced graphene oxide; AgNPs, silver nanoparticles; Ac-DEVD-CHO, N-Ac-Asp-Glu-Val-Asp-CHO; Ac-DEVD-pNA, acetyl-Asp-Glu-Val-Asp p-nitroanilide.