Fig. 1.

Pluripotent cells and the location of extragonadal teratomas in mice and humans. a Teratomas formed after manual injection of ES cells to the yolk sac and/or amniotic cavity of E9.5 embryos. ec, embryonal carcinoma; n, neural tissue; b, bone; kw, keratin whorl; c, cartilage; de, digestive epithelium; sm, striated (skeletal) muscle. b Locations and ages of mice developing teratomas, in this work and reported in the literature. Individual animals are assigned an arbitrary identifier (‘mouse number’) to account for the presence of multiple tumours in some animals. f, female; m, male; herm, hermaphrodite; nd, not determined. c Summary of teratoma location in humans (fetal and neonatal data taken from [57]; perinatal and childhood data from [35]). Data in piecharts is arranged clockwise starting with most frequent location at 12 o’clock