Fig 1. Serum concentration of FGF21 in cows overfed energy (OVE:N, n = 6) or fed to meet energy requirements (CON:N, n = 6) during the entire dry period, and receiving an intramammary LPS challenge at d 7 postpartum (OVE:Y, CON:Y).

The error bars represent SEM. The serum contraction of FGF21 tended to have an interaction among diet, time, and LPS (P = 0.08). No main effected of diet (P = 0.48) or LPS (P = 0.37) was observed, but the interaction diet × LPS was significant (P < 0.01). The statistical effects of diet, LPS, days are indicated: *Significant difference at 7 and 14 d postpartum within the same treatment groups; ^A,BSignificant difference among treatments (diet with or without LPS) at d 7 or 14 postpartum.