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. 2015 Oct 9;17:280. doi: 10.1186/s13075-015-0799-7

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© Hirata et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — 14-3-3η expression. a Clinical Disease Activity Index (CDAI)-defined disease states. The bar chart illustrates the relationship between 14-3-3η and/or C-reactive protein positivity and CDAI-defined disease status, b Changes between pre- and posttreatment. The box plot shows the change median levels of 14-3-3η over time, c Pairing by patient. The graph illustrates individual patients’ changes between pretreatment and posttreatment 14-3-3η serum levels. d Disease Activity Score in 28 joints with erythrocyte sedimentation rate (DAS28-ESR) based on changes in 14-3-3η expression. The box plot illustrates changes in median DAS28-ESR expression as 14-3-3η positivity changes over time. *Significance values were calculated using Dunn’s posttest