Table 3.

Pretreatment 14-3-3η positivity and association with disease state

		DAS28-ESR categorya			SDAI category			CDAI category
Cutpoint		≥0.19 ng/ml	≥0.40 ng/ml	≥0.80 ng/ml	≥0.19 ng/ml	≥0.40 ng/ml	≥0.80 ng/ml	≥0.19 ng/ml	≥0.40 ng/ml	≥0.80 ng/ml
Pretreatment	LR	10.6	16.3	25.2	3.7	9.7	16.3	6.2	8.8	14.0
	p-value	0.0011	<0.0001	<0.0001	0.16 (ns)	0.0077	0.0003	0.045	0.012	0.0009
1 yr	LR	10.1	5.1	2.6	2.2	1	1	2.2	1.1	0.8
	p-value	0.0064	0.079 (ns)	0.27 (ns)	0.34 (ns)	0.61 (ns)	0.61 (ns)	0.34 (ns)	0.57 (ns)	0.69 (ns)

Abbreviations: DAS28-ESR Disease Activity Score in 28 joints with erythrocyte sedimentation rate, SDAI Simple Disease Activity Index, CDAI Clinical Disease Activity Index, LR likelihood ratio, ns not significant

^aCalculated based on 145 patients for pretreatment and 146 for 1 yr