Table 1. PIK3CA mutation frequencies assessed by Sanger/qPCR in the entire group.
| N | % | ||
|---|---|---|---|
| PIK3CA mutation status by Sanger/qPCR | |||
| PIK3CAwt | 773 | 76.7 | |
| PIK3CAkin | 147 | 14.6 | |
| PIK3CAhel | 88 | 8.7 | |
| Total | 1008 | 100.0 | |
| PIK3CA aa change | PIK3CA nt change | ||
| H1047R | 3140A>G | 112 | 11.1 |
| E545K | 1633G>A | 47 | 4.7 |
| E542K | 1624G>A | 38 | 3.8 |
| H1047L | 3140A>T | 27 | 2.7 |
| H1047R,E542K | 3140A>G,1624G>A | 2 | 0.2 |
| H1047R,E545K | 3140A>G,1633G>A | 1 | 0.1 |
| H1047Y | 3139C>T | 1 | 0.1 |
| H1047H | 3142T>C | 1 | 0.1 |
| G1049D | 3146G>A | 1 | 0.1 |
| P1011S | 3031C>T | 1 | 0.1 |
| D1018N | 3052G>A | 1 | 0.1 |
| A1066V | 3197C>T hom | 1 | 0.1 |
| A1020T, H1047R, A1066T | 3058G>A, 3140A>G, 3196G | 1 | 0.1 |
| M1040I, p.A1066V | 3120G>A, 3197C>T | 1 | 0.1 |
PIK3CAhel, mutations present in the helical (and kinase) domain; PIK3CAkin, mutations present only in the kinase domain; PIK3CAwt, PIK3CA wild-type; aa, amino acid; nt, nucleotide.