Table 1. Parent-of-origin effects of APOB SNP rs1367117 a on adiposity and glycemic traits.
| Maternally-derived effect | Paternally-derived effect | |||||||
|---|---|---|---|---|---|---|---|---|
| Phenotype | No. of probands | Beta | SE b | p-value | Beta | SE b | p-value | P-value for maternal vs. paternal effects |
| BMI, kg/m 2 | ||||||||
| JPS (discovery) | 1235 | 1.437 | 0.527 | 0.0065 | 0.005 | 0.511 | 0.9927 | 0.0856 |
| FHS | 2228 | 0.791 | 0.250 | 0.0015 | -0.219 | 0.242 | 0.3650 | 0.0033 |
| FamHS | 773 | 1.319 | 0.436 | 0.0025 | -0.197 | 0.428 | 0.6455 | 0.0112 |
| ERF | 622 | -0.288 | 0.414 | 0.4863 | 0.340 | 0.413 | 0.4107 | 0.2791 |
| Combined (Z based) | 4858 | 7.8x10-6 | 0.6185 | 0.0005 | ||||
| Combined (inverse variance based) | 4858 | 0.752 | 0.180 | 3.1x10-5 | -0.087 | 0.176 | 0.6204 | |
| Waist circumference, cm | ||||||||
| JPS (discovery) | 1235 | 3.822 | 1.270 | 0.0027 | -0.646 | 1.249 | 0.6049 | 0.0260 |
| FHS | 2225 | 2.231 | 0.649 | 0.0006 | -0.244 | 0.632 | 0.6995 | 0.0056 |
| FamHS | 773 | 3.911 | 1.187 | 0.0010 | 0.279 | 1.161 | 0.8101 | 0.0254 |
| ERF | 631 | -3.037 | 3.110 | 0.3289 | -0.834 | 3.084 | 0.7868 | 0.6111 |
| Combined (Z based) | 4864 | 1.6x10-6 | 0.6007 | 0.0010 | ||||
| Combined (inverse variance based) | 4864 | 2.660 | 0.512 | 2.1x10-7 | -0.227 | 0.501 | 0.6502 | |
| Fasting glucose, mg/dL | ||||||||
| JPS (discovery) | 1068 | 0.342 | 1.160 | 0.7682 | -0.757 | 0.984 | 0.4417 | 0.5156 |
| FHS | 2153 | 1.315 | 0.382 | 0.0006 | -0.523 | 0.380 | 0.1694 | 0.0005 |
| FamHS | 761 | 0.036 | 0.653 | 0.9560 | -1.070 | 0.681 | 0.1163 | 0.2425 |
| ERF | 608 | 0.128 | 1.062 | 0.9041 | 0.279 | 1.050 | 0.7905 | 0.9208 |
| Combined (Z based) | 4590 | 0.0102 | -0.522 | 0.0636 | 0.0127 | |||
| Combined (inverse variance based) | 4590 | 0.875 | 0.304 | 0.0040 | -0.586 | 0.301 | 0.0520 | |
| Fasting insulin, mU/mL (natural log transformed) | ||||||||
| JPS (discovery) | 1102 | 0.104 | 0.059 | 0.0790 | -0.038 | 0.066 | 0.5585 | 0.1640 |
| FHS | 1960 | 0.051 | 0.024 | 0.0356 | 0.004 | 0.027 | 0.8823 | 0.1597 |
| FamHS | 761 | 0.129 | 0.046 | 0.0049 | -0.006 | 0.049 | 0.9016 | 0.0321 |
| ERF | 510 | 0.012 | 0.044 | 0.7856 | 0.017 | 0.044 | 0.6999 | 0.9376 |
| Combined (Z based) | 4333 | 0.0004 | 0.004 | 0.6347 | 0.0745 | |||
| Combined (inverse variance based) | 4333 | 0.062 | 0.018 | 0.0007 | 0.001 | 0.020 | 0.9566 | |
JPS, Jerusalem Perinatal Study; FHS, Framingham Heart Study; FamHS, Family Heart Study; ERF, Erasmus Rucphen Family
a Minor allele frequency (MAF) of SNP rs1367117 across studies: JPS 0.2, FHS 0.31, FamHS 0.34 (imputed data, R2 = 0.925), ERF 0.31.
b Standard errors (SEs) were calculated directly in JPS; in the other studies SEs were estimated by converting p-values into a z-statistic and setting: SE = beta/z.