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. 2015 Oct 9;10(10):e0140253. doi: 10.1371/journal.pone.0140253

Fig 1. Mice lacking wild-type Hras develop more PanIN lesions and have reduced survival in oncogenic Kras-driven models of pancreatic cancer.

Fig 1

(A) Representative H & E stained sections (arrowheads: normal acinar cells), (B) quantification of % total normal acinar area remaining per field (at 4x magnification, 4–5 fields from 12 mice, bar: mean ± S.E.M.), (C) % of fields (at 4x magnification) with no normal acinar tissue (based on the data from B), and (D) % of lobules with the indicated highest grade lesion (Nml: normal, 1A: PanIN-1A, 1B: PanIN-1B, bar: mean ± S.E.M.) of pancreata isolated from Hras +/+ versus Hras -/- KC mice at 9 months of age. (E) Kaplan-Meier curve of Hras +/+ (n = 45) versus Hras -/- (n = 23) KPC mice. ns: not significant. *P<0.05. ***P<0.0001.