Schematic representation of complexes target RNA:EGS. (A) Bimolecular substrate of human
RNase P. (B–D) Complexes between the hepatitis B pgRNA sequence (red),B, the mPR
mRNA (red), C and D, and the respective EGSs (blue). The nucleotides substituted between
EGSmPR1 and EGSmPR2 are circled. The arrow indicates the point of action of human RNase P.
Redrawn from Refs. 36, 60, 66.