Table 1.
Patient characteristics by cohort
| COG AALL0232 | SJ Total XV | Vanderbilt BioVU | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All (n = 2285) | Cases (n = 250) | Controls (n = 2035) | All (n = 361) | Cases (n = 68) | Controls (n = 293) | All (n = 309) | Cases (n = 82) | Controls (n = 227) | |
| Ancestry classification | |||||||||
| White | 1275 | 164 (12.9%) | 1111 (87.1%) | 260 | 53 (20.4%) | 207 (79.6%) | 216 | 57 (26.4%) | 159 (73.6%) |
| Black | 139 | 4 (2.9%) | 135 (97.1%) | 55 | 6 (10.9%) | 49 (89.0%) | 54 | 15 (27.8%) | 39 (72.2%) |
| Hispanic | 601 | 58 (9.7%) | 543 (90.3%) | 25 | 6 (24%) | 19 (75%) | 14 | 4 (28.6%) | 10 (71.4%) |
| Asian | 48 | 5 (10.4%) | 43 (89.6%) | 4 | 0 (0%) | 4 (100%) | 2 | 1 (50.0%) | 1 (50.0%) |
| Other | 222 | 19 (8.6%) | 203 (91.4%) | 17 | 3 (17.6%) | 14 (82.4%) | 23 | 5 (21.7%) | 18 (78.3%) |
| Gender | |||||||||
| Male | 1244 | 120 (9.6%) | 1124 (90.4%)) | 197 | 37 (18.8%) | 160 (81.2%) | 100 | 29 (29.0%) | 71 (71.0%) |
| Female | 1041 | 130 (12.5%) | 911 (87.5%) | 164 | 31 (18.9%) | 133 (81.1%) | 209 | 53 (25.4%) | 156 (74.6%) |
| Age (y, at diagnosis) | |||||||||
| 1-10 | 817 | 20 (2.4%) | 797 (97.6%) | 270 | 28 (10.4%) | 242 (89.6%) | 13 | 2 (15.4%) | 11 (84.6%) |
| ≥10 | 1468 | 230 (15.7%) | 1238 (84.3%) | 91 | 40 (44.0%) | 51 (56%) | 296 | 80 (27.0%) | 216 (73.0%) |
Patient characteristics are listed by osteonecrosis cases and controls within each cohort. Ancestry was genomically determined as described in “Methods.”