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T2-weighted MRI of MDA-MB-231/luc tumors before and after the intravenous administration of SPIONs-based contrast agents. A. SPIONs; B. Lip(Gd/Fe); C. scVEGF-Lip(Gd/Fe). Each yellow broken line represents a region-of-interest (ROI), in the MDA-MB-231/luc tumor. TE=35 ms.