Table 2.

Adrenals with secondary nodules genotyped for somatic mutations.

Adrenal	Genotype APA	Secondary nodule	Size of sec nodule (macro/micro)*	Genotype secondary nodule	APCC (n)	Genotype APCC
1	KCNJ5 p.Gly151Arg	A	micro	KCNJ5 p.Gly151Arg	1	neg
2	KCNJ5 p.Gly151Arg	A	micro	KCNJ5 p.Gly151Arg	1	neg
3	KCNJ5 p.Gly151Arg	A	micro	KCNJ5 p.Gly151Arg
		B	micro	KCNJ5 p.Gly151Arg
		C	micro	neg
4	neg	A	micro	KCNJ5 p.Gly151Arg	2	neg
5	CACNA1D p.Phe747Leu	A	micro	neg
6	CACNA1D p.Val259Asp	A	micro	neg
7	neg	A	micro	neg
8	neg	A	micro	neg
9	KCNJ5 p.Gly151Arg	A	micro	KCNJ5 p.Gly151Arg
10	neg	A	micro	neg	1	neg
		B	micro	neg
11	neg	A	micro	neg
		B	micro	neg
12	neg	A	micro	neg
		B	micro	neg
13	ATP1A1 p.Val332Gly	A	macro (6 mm)	neg
14	CACNA1D p.Pro1336Arg	A	micro	neg
15	CACNA1D p.Ala998Val	A	micro	KCNJ5 p.Gly151Arg
16	ATP1A1 p.Leu104Arg	A	micro	neg	1	neg
		B	micro	neg
17	KCNJ5 p.Gly151Arg	A	micro	KCNJ5 p.Gly151Arg	1	neg
18	KCNJ5 p.Gly151Arg	A	micro	neg
19	neg	A	micro	neg
20	CACNA1D p.Ile750Met	A	micro	neg
		B	micro	neg
21	KCNJ5 p.Gly151Arg	A	micro	neg
22	neg	A	micro	neg
23	neg	A	micro	neg
		B	micro	neg
24	CACNA1D p.Gly403Arg	A	micro	neg
		B	micro	KCNJ5 p.Gly151Arg
25	neg	A	macro (5 mm)	neg
26	KCNJ5 p.Gly151Arg	A	micro	neg
		B	micro	neg
27	CACNA1D p.Val1151Phe	A	micro	neg

APCC: aldosterone producing cell cluster.

^*Secondary nodules were defined as macroscopic nodules if larger than 5 mm of diameter; microscopic nodules were defined as nodules smaller than 5 mm located in a hyperplastic adrenal cortex.