Table.

Effects of 17β-estradiol on pulmonary hemodynamics in PAH

Parameters	CTL_P	CTL_E	SuHx_P	SuHx_E
mPAP (mmHg)	16.7±0.8	16.7±1.2	27.2±0.8*	24.1±1.5*
sPAP (mmHg)	21.5±1.4	22.4±1.3	37.5±1.2*	30.8±1.8*
dPAP (mmHg)	11.2±0.7	11.7±1.0	19.3±0.7*	19.2±1.4*
PP (mmHg)	12.0±0.5	12.0±0.5	18.2±1.0*	11.6±1.1†
SV (μl)	19.7±1.6	21.7±1.7	17.3±1.3	19.1±0.2
CO (ml/min)	10.6±0.8	10.0±0.8	9.8±0.7	9.5±0.9
CI (ml/min/g)	0.48±0.04	0.47±0.03	0.48±0.04	0.43±0.04
SV/PP (μl/mmHg)	1.76±0.13	1.89±0.12	0.98±0.12*	1.68±0.23†
tPVR (mmHg min/ml)	1.6±0.1	1.5±0.1	2.9±0.3*	2.8±0.5*

Mean ± SE values (n = 6–10 per group). mPAP, sPAP, and dPAP indicate mean, systolic and diastolic PA pressure, respectively; PP, pulse pressure, SV, stroke volume; CO, cardiac output; CI, cardiac index; tPVR (= mPAP/CO), total vascular resistance; CTL, control; P, placebo-treated; E, estradiol-treated.

^*P<0.05 vs Control;

^†P<0.05 vs Placebo.