Figure 8. IRF1 and 7 involvement in the effects of IFN-β on cytokine production.

DCs were generated from WT Irf1^−/− (A) and Irf7^−/− (B) mice. Cells were pretreated with IFN-β for 1 h, followed by LPS stimulation for 12 h (for IL-23) and 24 h (for IL-12 and IL-10). Supernatants were analyzed for cytokine secretion by ELISA. One of 3 independent experiments is shown. Results represent the means ± sd. *P < 0.05, **P < 0.01, compared with LPS alone.