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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurogastroenterol Motil. 2015 Jul 17;27(10):1509–1514. doi: 10.1111/nmo.12635

Figure 2. Endoscopically transplanted enteric neuronal stem cells survive and differentiate in Ednrb−/− mouse colon in vivo.

Figure 2

Enteric neuronal stem cells from Actb-DsRed mice were colonoscopically injected into the distal colon of recipient Ednrb−/− mice. In vivo neuronal differentiation 1 week after transplantation is confirmed by co-localization of DsRed with neuronal marker, PGP (; A). Differentiation into glia and neuronal subtypes is shown by immunoreactivity to glial marker, S100 (B), and neuronal subtype markers: calretinin (CR; C), choline acetyltransferase (ChAT; D), neuronal nitric oxide synthase (NOS; E). Scale bar is 50 μm. Scale bar is the same for A–E.