TABLE 5 .
C. albicans genes most upregulated during systemic infection
| orf19 name | Gene name | Description | Fold change compared to in vitro growth (log2 values)a |
|||
|---|---|---|---|---|---|---|
| Gm, 2 h | Gm, 24 h | Mm, 16 h | Mm, 48 h | |||
| orf19.7455 | orf19.7455 | Ortholog of C. dubliniensis CD36: Cd36_86630 | 11.38 | 11.24 | 11.80 | 11.60 |
| orf19.1321 | HWP1 | Hyphal cell wall protein | 10.46 | 9.89 | 10.63 | 11.54 |
| orf19.6028 | HGC1 | Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis |
9.78 | 9.55 | 10.39 | 11.05 |
| orf19.3374 | ECE1 | Hypha-specific protein | 8.73 | 9.26 | 9.40 | 11.04 |
| orf19.1363 | orf19.1363 | Putative protein of unknown function | 7.85 | 7.38 | 8.53 | 10.45 |
| orf19.5636 | RBT5 | GPI-linked cell wall protein | 6.80 | 9.50 | 8.43 | 9.85 |
| orf19.2060 | SOD5 | Cu and Zn-containing superoxide dismutase | 8.55 | 6.97 | 8.43 | 9.59 |
| orf19.7094 | HGT12 | Glucose, fructose, mannose transporter | 13.09 | 12.62 | 8.41 | 12.76 |
| orf19.1816 | ALS3 | Cell wall adhesin | 8.02 | 4.20 | 8.31 | 8.59 |
| orf19.5585 | SAP5 | Secreted aspartyl proteinase | 8.22 | 8.57 | 8.25 | 10.22 |
| orf19.1822 | UME6 | Zn(II)2Cys6 transcription factor | 7.86 | 7.86 | 8.11 | 8.87 |
| orf19.2457 | orf19.2457 | Protein of unknown function | 9.59 | 8.99 | 7.91 | 8.41 |
| orf19.5952 | orf19.5952 | Protein of unknown function | 3.11 | 8.13 | 7.84 | 8.73 |
| orf19.2062 | SOD4 | Cu and Zn-containing superoxide dismutase | 7.50 | 9.64 | 7.71 | 6.64 |
| orf19.2061 | orf19.2061 | Ortholog of C. albicans WO-1: CAWG_03846 | 10.23 | 6.52 | 7.56 | 9.61 |
| orf19.4599 | PHO89 | Putative phosphate permease | 6.87 | 7.54 | 7.21 | 7.20 |
| orf19.1264 | CFL2 | Oxidoreductase; iron utilization | 5.46 | 8.23 | 7.08 | 6.86 |
| orf19.1930 | CFL5 | Ferric reductase | 6.92 | 12.92 | 6.96 | 9.38 |
| orf19.113 | CIP1 | Possible oxidoreductase | 7.88 | 7.90 | 6.82 | 8.31 |
| orf19.6148 | orf19.6148 | Homolog of nuclear distribution factor NudE, NUDEL | 4.84 | 6.29 | 6.69 | 8.66 |
Mm, M. musculus; Gm, G. mellonella.