TABLE 6 .
List of C. albicans genes regulated “in vivo” and categorized according to enriched GO termsa
| Group and GO term (biological process) |
Enrichment fractionc |
Log odds ratio |
Adjusted P value |
Gene list |
|---|---|---|---|---|
| Positive z scores | ||||
| Regulation of response to stimulus (GO:0048583)b |
47/252 | 0.88 | 0.03 |
HGC1, UME6, PTP3, CEK1, orf19.6705, HGT1, SLN1, FAV1, CST5,BEM2, PRA1, KEX2, RPN4, ALS1, orf19.2565, CLA4, orf19.3501, orf19.4792, GCN2, HSP70, RIM101, RGS2, MSB2, IQG1, RAX1, MKK2, CCN1, SAP4, BUD2, LTE1, CAG1, GPA2, CZF1, ZCF30, ZCF2, GEA2, SKN7, TEA1, AHR1, CPP1, TEC1, HRR25, SET1, CRZ1, RAS1, PPR1, orf19.321 |
| Iron ion homeostasis (GO:0055072) |
16/41 | 1.95 | 0.00 |
HMX1, HAP43, FTR1, IRO1, FRP1, RBT5, CSR1, CFL2, CSA2,CCC2, FET34, CSA1, ISU1, SEF1, ALS3 |
| Regulation of filamentous growth (GO:1900443) |
18/60 | 1.57 | 0.03 |
HGC1, UME6, CEK1, SLN1, CLA4, CCN1, GPA2, CZF1, ZCF30,ZCF2, SKN7, TEA1, AHR1, CPP1, TEC1, CRZ1, RAS1, PPR1 |
| Biofilm formation (GO:0042710) |
30/137 | 1.11 | 0.04 |
HWP1, RBT5, ECE1, TRY5, HYR1, HGC1, PHR1, ALS3, PGA7, CSA1, CST5, CSR1, ALS1, TRY4, BCR1, ARG81, CSH1, SUN41, CSA2, ZNC1, TRY6,PBR1, BRG1, VPS1, CZF1, AHR1, TEC1, IPT1, RAS1, GUP1 |
| Pathogenesis (GO:0009405) | 41/225 | 0.85 | 0.09 |
HWP1, PHR1, UME6, SOD5, FTR1, ALS3, FET34, CEK1, SAP5,ICL1, RBT4, HAP43, KEX2, IFF4, ALS1, IRE1, CLA4, HEX1, CSH1, SFL2, HGT4, RIM101, IRO1, SUN41, CHS3, BRG1, SAP4, MTLA1, CTF1, BUD2, MIT1, IRS4, SLK19, GPA2, AHR1, CPP1, CKA2, TEC1, DUR1,2, SET1, RAS1 |
| Biological adhesion (GO:0022610) |
21/86 | 1.27 | 0.08 |
HWP1, RBT5, HYR1, PHR1, ALS3, SAP5, DFI1, PRA1, IFF4,ALS1, BCR1, CSH1, SUN41, MSB1, PBR1, SAP4, IRS4, AHR1, TEC1, SAP10, RAS1 |
| Negative z scores | ||||
| Cellular amino acid biosynthesis (GO:0008652) |
44/132 | 2.02 | 0.00 |
ILV3, HOM2, ARO3, ILV6, HIS1, GLO2, HIS5, LEU4, PDB1, TRP2, ANB1, THR4, orf19.1626, HOM6, orf19.2306, PRO1, CYS4, ARO2, HOM3, HIS4, orf19.2286, BAT21, orf19.3810, ASN1, MET16, ILV1, SER1, ARO4, MET2, TRP4, GLN1, MMD1, THR1, ARO1, SER2, GLT1, orf19.7152, ILV5, SAM2, SER33, MIS11, GSH2, CBF1, IDP1 |
| Glycolysis (GO:0006096) | 11/16 | 3.07 | 0.00 | CDC19, FBA1, GPM1, TPI1, ENO1, TDH3, PGK1, PDA1, ADH1,PFK1, PGI1 |
| Induction of host defense response (GO:0044416) |
9/21 | 2.39 | 0.00 | CDC19, FBA1, TPI1, ENO1, TDH3, PGK1, SSB1, ADH1, IMH3 |
| Mitochondrial electron transport (GO:0006122) |
6/10 | 2.87 | 0.01 | RIP1, CYT1, QCR2, QCR8, orf19.913.2, CYC1 |
| Translation (GO:0006412) | 95/404 | 1.52 | 0.00 |
RPP1A, RPS3, orf19.3649, orf19.5812, RPS24, RPP2A, RPS17B, RPL42, RPL2, RPL37B, RPL39, DED81, RPP2B, ANB1, orf19.5943.1, SUI3, RPL20B, RPS19A, RPL28, RPL30, RPS21, ARC1, RPL16A, RPS23A, RPL18, orf19.6220.4, RPL15A, RPL5, RPS1, SSZ1, TYS1, RPS4A, RPL14, TMA19, RPL27A, RPL43A, RPS18, RPL10, orf19.5684, SSB1, orf19.4149.1, TEF2, RPS20, DRG1, EIF4E, CAM1-1, RPL23A, RPL17B, RPL3, orf19.3341, RPL19A, RPL13, RPL21A, RPS9B, RPS28B, GRS1, SIS1, GCD11, RPS21B, orf19.6882.1, RPS15, RPS7A, MMD1, HCR1, RPS8A, TIF, YST1, SUP35, RPS12, GUS1, RPL6, RPL4B, RPS6A, FRS1, RPS5, KRS1, RPS16A, RPL25, RPL9B, RPL40B, RPS22A, CDC60, UBI3, RPL10A, orf19.3572.3, TEF1, RPL38, EFB1, THS1, RPP0, TIF34, RPP1B, GCD6, orf19.2478.1, RPL11 |
a
Log odds ratios and adjusted P values were obtained by performing GO term enrichment analysis with GOEAST (89). Only selected GO terms are listed.
b
Corresponding GO term numbers are given in parentheses.
c
Enrichment fraction was obtained by the ratio between the gene lists and the total number of genes present in a given GO term.