TABLE 1 .
Blood transcriptional module enrichment analysis of genes differentially expressed between latent M. tuberculosis infection and TBa
| Module ID | Module title | No. of genes in a module |
AUC | q value |
|---|---|---|---|---|
| DC.M3.4 | IFN | 51 | 0.88 | 2.61E−18 |
| DC.M5.12 | IFN | 57 | 0.77 | 2.48E−10 |
| DC.M1.2 | IFN | 24 | 0.87 | 4.57E−08 |
| LI.M47.0 | Enriched in B cells (I) | 47 | 0.73 | 1.94E−06 |
| LI.M75 | Antiviral IFN signature | 22 | 0.83 | 4.40E−06 |
| LI.M67 | Activated dendritic cells | 11 | 0.95 | 8.61E−06 |
| LI.M47.1 | Enriched in B cells (II) | 34 | 0.74 | 5.45E−05 |
| LI.M127 | Type I IFN response | 12 | 0.90 | 5.69E−05 |
| DC.M4.10 | B cell | 31 | 0.75 | 5.69E−05 |
| LI.M37.1 | Enriched in neutrophils (I) | 49 | 0.30 | 5.69E−05 |
| LI.M111.1 | Viral sensing and immunity; IRF2 targets network (II) | 11 | 0.89 | 2.06E−04 |
| LI.M150 | Innate antiviral response | 12 | 0.85 | 5.53E−04 |
| DC.M3.2 | Inflammation | 118 | 0.39 | 5.58E−04 |
| LI.M226 | Proteasome | 12 | 0.83 | 1.72E−03 |
| DC.M3.5 | Cell cycle | 143 | 0.41 | 4.24E−03 |
| LI.M68 | RIG-1-like receptor signaling | 10 | 0.83 | 4.27E−03 |
| DC.M6.2 | Mitochondrial respiration | 144 | 0.41 | 4.75E−03 |
| LI.M5.0 | Regulation of antigen presentation and immune response | 79 | 0.62 | 5.20E−03 |
| DC.M4.13 | Inflammation | 77 | 0.39 | 1.18E−02 |
| DC.M2.3 | Erythrocytes | 66 | 0.61 | 1.50E−02 |
| LI.M32.8 | Cytoskeletal remodeling | 10 | 0.79 | 1.69E−02 |
| LI.M69 | Enriched in B cells (VI) | 20 | 0.70 | 2.03E−02 |
| DC.M6.12 | Mitochondrial stress | 66 | 0.39 | 2.35E−02 |
| DC.M4.15 | T cells | 41 | 0.64 | 2.67E−02 |
| LI.M156.0 | Plasma cells and B cells; immunoglobulins | 24 | 0.67 | 2.88E−02 |
| LI.M111.0 | Viral sensing and immunity; IRF2 targets network (I) | 17 | 0.71 | 2.88E−02 |
| LI.M7.1 | T cell activation (I) | 48 | 0.62 | 3.09E−02 |
| LI.M14 | T cell differentiation | 12 | 0.74 | 3.09E−02 |
| LI.M112.0 | Complement activation (I) | 17 | 0.70 | 3.91E−02 |
| LI.M209 | Lysosome | 8 | 0.79 | 3.93E−02 |
| DC.M4.1 | T cell | 53 | 0.61 | 4.06E−02 |
| LI.S2 | B cell surface signature | 168 | 0.56 | 4.06E−02 |
a
The module title is the title of the blood transcription module according to references 17 and 18. In the module ID, the prefix “DC” refers to BTMs according to Chaussabel et al. (18) and the prefix “LI” refers to BTMs according to Li et al. (17). Only modules with a functional annotation are shown. The AUC is the area under the curve, and the q value is the adjusted P value after correction for multiple testing (Benjamini-Hochberg). E, exponential notation (e.g., E–03 represents ×10−3); IFN, interferon; IRF2, interferon regulatory factor 2.