TABLE 2 .

Blood transcriptional modules with significant average correlation coefficients between the differences in DNA methylation and gene expression in comparison of LTBI and TB^a

Module ID	Module title	r	q value
LI.M200	Antigen processing and presentation	0.25	3.86E−16
LI.M95.0	Enriched in antigen presentation (II)	0.22	3.43E−14
DC.M8.83	Immune responses	0.22	1.68E−10
LI.M71	Enriched in antigen presentation (I)	0.15	9.94E−08
LI.M37.0	Immune activation—generic cluster	−0.07	5.50E−06
LI.M17.3	Hox cluster IV	−0.25	9.40E−06
LI.S2	B cell surface signature	0.07	1.06E−05
LI.M146	MHC-TLR7-TLR8 cluster	0.09	0.0002
LI.M168	Enriched in dendritic cells	−0.28	0.001
LI.M5.0	Regulation of antigen presentation and immune response	0.09	0.002
LI.M17.1	Hox cluster II	−0.03	0.003
LI.M17.0	Hox cluster I	−0.19	0.003
LI.M96	Hox cluster V	−0.03	0.004
DC.M5.15	Neutrophils	−0.11	0.005
LI.M24	Cell activation (IL-15, IL-23, TNF)	−0.18	0.009
LI.M74	Transcriptional targets of glucocorticoid receptor	−0.12	0.02
DC.M4.13	Inflammation	−0.18	0.02
LI.M160	Leukocyte differentiation	−0.09	0.02
LI.M37.1	Enriched in neutrophils (I)	−0.26	0.03
LI.M75	Antiviral IFN signature	−0.14	0.03
DC.M4.2	Inflammation	−0.22	0.03
LI.M112.0	Complement activation (I)	−0.11	0.04
DC.M3.2	Inflammation	−0.18	0.04
LI.M57	Immunoregulation—monocytes, T and B cells	−0.21	0.04

^a“Module ID” refers to the original publication, where the prefix “LI” refers to BTMs according to Li et al. (17), and the prefix “DC” refers to BTMs according to Chaussabel et al. (18). Only modules with a functional annotation are shown. r is the average correlation coefficient in the module, and the q value is the P value in a randomization test corrected for multiple testing. IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.