TABLE 1 .
Responses to inoculation with live H. ducreyi 35000HPa
| Volunteer no., gender |
No. of days infected |
Site no. |
Inoculum (CFU) |
Clinical endpoint |
Induration size and presence of pustule(s) on postinoculation dayb: |
|||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 5 | Endpoint | |||||
| 395, F | 7 | 1 | 32 | R | 6 × 6 (−) | 9 × 9 (−) | R | R |
| 2 | P | 6 × 6 (−) | 8 × 9 (−) | 4 × 4 (−) | 4 × 4 (+) | |||
| 3 | P | 5 × 5 (−) | 5 × 8 (−) | 4 × 4 (−) | 4 × 4 (+) | |||
| 396, F | 13 | 1 | 32 | R | 3 × 3 (−) | 4 × 4 (−) | 6 × 7 (−) | R |
| 2 | R | ND | ND | ND | ND | |||
| 3 | R | ND | ND | ND | ND | |||
| 398, M | 6 | 1 | 63 | P | 5 × 5 (−) | 5 × 6 (−) | 9 × 7 (+) | 10 × 15 (+) |
| 2 | P | 4 × 4 (−) | 5 × 5 (−) | 5 × 5 (+) | 6 × 6 (+) | |||
| 3 | P | 5 × 5 (−) | 5 × 5 (−) | 6 × 5 (+) | 5 × 6 (+) | |||
| 391A, M | 7 | 1 | 63 | R | 4 × 4 (−) | R | R | R |
| 2 | R | 2 × 2 (−) | 2 × 2 (−) | R | R | |||
| 3 | R | 3 × 3 (−) | 4 × 4 (−) | 3 × 2 (−) | R | |||
| 406, M | 6 | 1 | 69 | R | 2 × 2 (−) | 2 × 2 (−) | R | R |
| 2 | P | 4 × 4 (−) | 3 × 3 (−) | 4 × 4 (+) | 5 × 5 (+) | |||
| 3 | P | 4 × 4 (−) | 3 × 3 (−) | 15 × 7 (+) | 7 × 7 (+) | |||
| 407, M | 9 | 1 | 69 | R | 4 × 4 (−) | 5 × 5 (−) | Rc | R |
| 2 | R | 4 × 4 (−) | 5 × 5 (−) | R | R | |||
| 3 | R | 4 × 4 (−) | 5 × 5 (−) | R | R | |||
| 408, F | 8 | 1 | 35 | R | 2 × 2 (−) | 3 × 3 (−) | 3 × 3 (−) | R |
| 2 | R | 4 × 4 (−) | R | R | R | |||
| 3 | R | 3 × 3 (−) | R | R | R | |||
| 409, M | 7 | 1 | 35 | P | 3 × 3 (−) | 3 × 3 (−) | 8 × 8 (+) | 12 × 10 (+) |
| 2 | R | 3 × 3 (−) | 2 × 2 (−) | R | R | |||
| 3 | P | 4 × 4 (−) | 5 × 4 (−) | 5 × 5 (+) | 12 × 12 (+) | |||
a
Abbreviations: F, female; M, male; ND, no disease; R, resolved; P, pustule.
b
Induration dimensions are reported in millimeters; + and − symbols in parentheses indicate the presence or absence of pustules, respectively.
c
Subject 407 did not achieve the endpoint on day 5 because disease was present at sites injected with the mutant strain.