Table 1.

Selected miRNAs important for progression of osteolytic metastasis.

miRNA	Function(s)	Reference(s)
miR-16	Potential circulating biomarker for bone metastasis	[3]
miR-21	Functions as an oncogene	[32]
	Highly expressed during osteoclastogenesis	[24]
	Highly detected in osteoclast EVs	[6]
miR-31	Inhibits breast cancer metastasis	[33]
	Promotes ring-shaped mature osteoclast formation	[34]
miR-33a	Inhibits bone metastasis by targeting PTHrP	[31]
	Downregulated during osteoclastogenesis	[3]
miR-34a	Inhibits osteoclast differentiation by targeting Tgif2	[29]
	Attenuates bone metastasis	[29]
miR-125a	Tumor suppressor in breast cancer	[32]
	Upregulated during osteoclastogenesis	[28]
	Inhibits osteoclast differentiation by targeting TRAF6	[35]
miR-133a	Inhibits osteoclast differentiation by targeting Mitf and Mmp14	[3]
miR-141	Inhibits osteoclast differentiation by targeting Mitf and Calcr	[3]
miR-155	Highly expressed in invasive tumors	[32]
	Inhibits osteoclastogenesis by repressing MITF and PU.1	[25]
	Deficiency promotes tumor growth in vivo	[36]
miR-190	Inhibits osteoclast differentiation by targeting Calcr	[3]
miR-192	Inhibits angiogenesis and decreases bone metastasis	[37]
miR-219	Inhibits osteoclast differentiation by targeting Mitf and Traf6	[3]
miR-223	Inhibits murine osteoclast differentiation	[21,22]
	Decreases breast cancer cell proliferation	[38]
miR-326	Potential circulating biomarker for bone metastasis	[39]
miR-378	Potential circulating biomarker for bone metastasis	[3]
	Highly detected in osteoclast EVs	[6]
	Promotes cell survival, tumor growth, and angiogenesis	[40]
miR-204/211/379	Inhibits TGF-β-induced IL-11 production	[30]