Table 2.
Top 50 genes significantly associated with age across 361 samples
| Gene | Min (p) | Max |β| |
|---|---|---|
| H3F3B | 3.39E-13 | 0.0098 |
| AHNAK | 6.87E-12 | 0.0086 |
| HOXB2 | 1.01E-11 | −0.0184 |
| CRIM1 | 5.34E-11 | 0.0124 |
| NAP1L1P3 | 9.74E-11 | 0.0154 |
| ARFGAP2 | 3.56E-10 | 0.0069 |
| WDR6 | 4.47E-10 | 0.0069 |
| DLEU1 | 8.61E-10 | −0.0117 |
| USP6 | 1.43E-09 | 0.0133 |
| TCF25 | 2.70E-09 | 0.0064 |
| SCN4B | 3.13E-09 | −0.0289 |
| ZNF274 | 3.87E-09 | 0.0129 |
| HDAC4 | 4.04E-09 | 0.0155 |
| SH3BP5 | 5.04E-09 | 0.0114 |
| SART3 | 5.32E-09 | 0.0050 |
| CASC3 | 9.73E-09 | 0.0061 |
| CIRBP | 1.14E-08 | 0.0091 |
| HIST1H2BN | 1.49E-08 | −0.0065 |
| FUBP1 | 1.74E-08 | 0.0058 |
| FAM171A1 | 1.94E-08 | −0.0113 |
| NPPA | 1.97E-08 | −0.0048 |
| TMEM59L | 2.39E-08 | −0.0080 |
| UBE2O | 2.79E-08 | −0.0060 |
| FEZ2 | 2.83E-08 | 0.0126 |
| ALS2CL | 3.15E-08 | −0.0063 |
| C1S | 3.22E-08 | 0.0137 |
| RXRG | 3.23E-08 | −0.0095 |
| NT5C2 | 3.64E-08 | 0.0115 |
| TRMT112 | 4.42E-08 | 0.0116 |
| PRNP | 4.68E-08 | 0.0094 |
| NOL9 | 6.31E-08 | 0.0049 |
| RBM10 | 6.66E-08 | 0.0056 |
| ANP32B | 6.71E-08 | 0.0092 |
| TOMM40L | 6.74E-08 | −0.0144 |
| HTR5A | 7.21E-08 | −0.0051 |
| SEC24C | 7.78E-08 | 0.0060 |
| BUB3 | 7.98E-08 | 0.0036 |
| DAAM2 | 8.92E-08 | −0.0091 |
| HSPA1A | 8.93E-08 | 0.0091 |
| SEZ6L2 | 9.12E-08 | −0.0046 |
| MRPL4 | 9.38E-08 | −0.0080 |
| CMC2 | 1.04E-07 | −0.0091 |
| NR1D1 | 1.04E-07 | −0.0054 |
| ENDOG | 1.11E-07 | −0.0126 |
| MRPL48 | 1.25E-07 | −0.0066 |
| FRAT2 | 1.31E-07 | −0.0064 |
| SYNRG | 1.31E-07 | 0.0040 |
| PPIC | 1.38E-07 | −0.0076 |
| POMT1 | 1.47E-07 | 0.0061 |
| DECR2 | 1.65E-07 | 0.0043 |
The minimum p and maximum β values were calculated for genes present in both array datasets, adjusted for sex and study effect. A positive β value implicates increasing gene expression with age. For the full list of 957 genes, see Table S2 in Additional file 2