Table 3.

Gene set enrichment analysis for the 484 genes upregulated with age and the 473 downregulated

Upregulated sets	ES	NES	FDR q value
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	0.80	2.32	0.0047
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	0.89	2.18	0.0133
REACTOME_COMPLEMENT_CASCADE	0.89	2.15	0.0138
BIOCARTA_COMP_PATHWAY	0.86	2.21	0.0148
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS	0.75	2.07	0.0288
BIOCARTA_CLASSIC_PATHWAY	0.90	2.04	0.0361
Downregulated sets
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT	−0.76	−2.90	0.0000
MITOCHONDRION	−0.59	−2.70	0.0000
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE	−0.81	−2.48	0.0008
MITOCHONDRIAL_ENVELOPE	−0.74	−2.39	0.0010
MITOCHONDRIAL_MEMBRANE	−0.74	−2.37	0.0011
MITOCHONDRIAL_PART	−0.74	−2.39	0.0012
KEGG_PARKINSONS_DISEASE	−0.73	−2.40	0.0013
ORGANELLE_INNER_MEMBRANE	−0.74	−2.30	0.0014
ORGANELLE_ENVELOPE	−0.68	−2.33	0.0015
MITOCHONDRIAL_INNER_MEMBRANE	−0.74	−2.30	0.0015
ENVELOPE	−0.68	−2.26	0.0019
KEGG_OXIDATIVE_PHOSPHORYLATION	−0.64	−2.23	0.0024
REACTOME_PYRUVATE_METABOLISM	−0.81	−2.22	0.0025
COFACTOR_METABOLIC_PROCESS	−0.69	−2.19	0.0037
KEGG_ALZHEIMERS_DISEASE	−0.60	−2.07	0.0117
MITOCHONDRIAL_MEMBRANE_PART	−0.74	−2.08	0.0123
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_	−0.70	−2.02	0.0161
REACTOME_GLUCOSE_METABOLISM	−0.70	−2.03	0.0162
REACTOME_GLUCONEOGENESIS	−0.77	−2.01	0.0187
ION_TRANSPORT	−0.82	−1.99	0.0199
COENZYME_METABOLIC_PROCESS	−0.82	−2.00	0.0200
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	−0.81	−1.96	0.0246
HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	−0.78	−1.94	0.0283
INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	−0.78	−1.91	0.0340
ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	−0.50	−1.90	0.0378
MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	−0.78	−1.89	0.0380
KEGG_CITRATE_CYCLE_TCA_CYCLE	−0.77	−1.89	0.0385