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. 2015 Oct 9;15:668. doi: 10.1186/s12885-015-1661-7

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© De Falco et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — MYC mRNA and protein expression in MYC translocation-positive and -negative BL cases. a Quantitative-RT-PCR. The expression of MYC was analysed at the mRNA level in cases either carrying or lacking the translocation. RT-qPCR results show the up-regulation of the gene also in the absence of MYC translocation; (b-c) Immunohistochemistry. In the exemplifying MYC translocation-positive case (b), a strong staining in about 95 % of neoplastic cells is shown in contrast to the MYC translocation-negative one (c), in which the staining intensity was present in about 60 % of cells. b-c: MYC stain. Original Magnification (O.M): 20x