Table 2.
Clinical parameters (Mean ± SD) | Full cohort with complete case | Propensity score-matched cohort | ||||||
---|---|---|---|---|---|---|---|---|
MM group paired diff.a (N = 7493) | Control group paired diff.a (N = 3800) | Diff. in diff. (MM group—control group) | P value | MM group paired diff.a (N = 3400) | Control group paired diff.a (N = 3400) | Diff. in diff. (MM group—control group) | P value | |
HbA1c, % | −0.04 ± 1.08 | 0.29 ± 0.68 | −0.32 | <0.001* | 0.19 ± 0.79 | 0.28 ± 0.69 | −0.09 | <0.001* |
SBP, mmHg | −2.86 ± 19.33 | −1.91 ± 19.04 | −0.95 | 0.013* | −3.07 ± 19.40 | −1.95 ± 18.95 | −1.12 | 0.016* |
DBP, mmHg | −2.20 ± 10.64 | −1.42 ± 10.16 | −0.78 | <0.001* | −2.25 ± 10.54 | −1.30 ± 10.15 | −0.95 | <0.001* |
LDL-C, mmol/L | −0.58 ± 0.90 | −0.48 ± 0.89 | −0.10 | <0.001* | −0.71 ± 0.92 | −0.44 ± 0.87 | −0.27 | <0.001* |
TC/HDL-C ratio | −0.69 ± 1.04 | −0.60 ± 1.22 | −0.09 | <0.001* | −0.78 ± 1.07 | −0.56 ± 1.01 | −0.23 | <0.001* |
Triglyceride, mmol/L | −0.21 ± 0.84 | −0.14 ± 0.75 | −0.07 | <0.001* | −0.18 ± 0.73 | −0.14 ± 0.77 | −0.03 | 0.059 |
BMI, kg/m2 | −0.30 ± 1.55 | −0.05 ± 1.46 | −0.25 | <0.001* | −0.19 ± 1.54 | −0.08 ± 1.43 | −0.11 | 0.002* |
MM metformin monotherapy, HbA1c haemoglobin A1c, SBP systolic blood pressure, DBP diastolic blood pressure, LDL-C low density lipoprotein-cholesterol, TC total cholesterol, HDL-C high density lipoprotein-cholesterol, BMI body mass index, DM diabetes mellitus
* Significant with p value <0.05 by independent t test
aPaired difference (Post—baseline)