Table 5.

Gene copy number variation results from aCGH on seven sample pairs

Sample		Loss of chromosome	Gain of chromosome	Recurrent/De novo	Note
Ipsilateral 2	First tumour			Likely to be de novo
	Second tumour	2p, 3p (partial),	7q, 8q, 10p (partial), 19p
Ipsilateral 6	First tumour	3p (partial)	17q (partial)	Likely to be recurrent	The second tumour still retains the variation of the primary tumour, especially gain of 17q12 (Her2)
	Second tumour	3p (partial), 4q, 8p, 9p, 10p, 11q, 13, 18	1q (partial), 12p, 14p, 17q (partial), 19p
Ipsilateral 11	First tumour		5q (partial), 8q (partial), 17q (partial)	Recurrent	Whole genome variation of primary and second tumour overlaid exactly
	Second tumour		5q (partial), 8q (partial), 17q (partial)
Ipsilateral 12	First tumour	6q, 11q, 12q, 13	1q, 11p (partial), 12p, 12q (partial), 19	Likely to be recurrent	Similar overall patterns in chromosome 11, 12 and 19
	Second tumour	2q (partial), 3p (partial), 4, 6q, 7q (partial), 11q, 12q, 13	1q, 11p (partial), 12p, 12q (partial), 15, 19
Contralateral 3	First tumour	6q, 11q, 18	1q, 11p, 17q (partial)	Likely to be de novo
	Second tumour	6q, 16q, 22	1q, 16p, Xq
Contralateral 10	First tumour	3p	6p, 8q	Likely to be recurrent	Similar overall patterns, especially in chromosome 8, 21 and 22
	Second tumour		6p, 8q
Contralateral 13	First tumour		3p (partial), 8q, 11q (partial)	Likely to be recurrent
	Second tumour		3p (partial), 8q, 11q (partial)