Table 2.

GEP variability performance results

Variability Score	Scores ≤ Threshold %	PPV %	NPV %	Sensitivity %	Specificity %
		(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)
0.1	0.0	17.0 (−−)	-	100.0 (90.3–100)	0.0 (0.0–6.5)
0.2	1.1	17.2 (11.6–23.8)	100.0 (−−)	100.0 (90.3–100)	1.8 (0.0–9.7)
0.3	3.3	17.8 (12.3–24.7)	100.0 (−−)	100.0 (90.3–100)	5.5 (1.1–15.1)
0.4	7.7	19.0 (13.1–26.9)	100.0 (−−)	100.0 (90.3–100)	12.7 (5.3–24.5)
0.5	16.5	22.0 (15.2–30.8)	100.0 (−−)	100.0 (90.3–100)	27.3 (16.1–41.0)
0.6	24.2	23.3 (15.7–33.0)	97.0 (91.4–100.0)	94.4 (81.3–99.3)	36.4 (23.8–50.4)
0.7	33.0	23.2 (15.4–33.7)	92.8 (85.4–97.8)	83.3 (67.2–93.6)	43.6 (30.3–57.7)
0.8	42.9	25.2 (16.3–37.1)	91.4 (84.2–96.5)	75.0 (57.8–87.9)	54.5 (40.6–68.0)
0.9	56.0	29.7 (18.5–46.0)	90.3 (83.9–95.2)	63.9 (46.2–79.2)	69.1 (55.2–80.9)
1.0	62.6	26.0 (14.8–41.8)	87.4 (80.1–92.9)	50.0 (32.9–67.1)	70.9 (57.1–82.4)
1.1	68.1	27.8 (15.3–46.5)	87.0 (80.4–92.4)	44.4 (27.9–61.9)	76.4 (63.0–86-8)
1.2	71.4	29.9 (16.3–51.0)	87.0 (80.3–92.2)	41.7 (25.5–59.2)	80.0 (67.0–89.6)
1.3	76.9	29.4 (14.6–53.4)	86.0 (79.3–91.3)	33.3 (18.6–51.0)	83.6 (71.2–92.2)
1.4	83.5	31.9 (13.5–63.2)	85.3 (78.7–90.6)	25.0 (12.1–42.2)	89.1 (77.8–95.9)
1.5	87.9	35.4 (13.5–75.8)	84.9 (78.5–90.1)	19.4 (8.2–36)	92.7 (82.4–98.0)
1.6	92.3	29.4 (5.9–100.0)	83.9 (77.1–89.4)	11.1 (3.1–26.1)	94.5 (84.9–98.9)
1.7	94.5	31.9 (0.0–100.0)	83.7 (77.1–89.1)	8.3 (1.8–22.5)	96.4 (87.5–99.6)
1.8	97.8	23.8 (−−)	83.2 (76.6–88.6)	2.8 (0.1–14.5)	98.2 (90.3–100.0)
1.9	98.9	100.0 (−−)	83.4 (77.0–88.7)	2.8 (0.1–14.5)	100.0 (93.5–100.0)
2.0	98.9	100.0 (−−)	83.4 (77.0–88.7)	2.8 (0.1–14.5)	100.0 (93.5–100.0)
2.1	100.0	--- (−−)	83.0 (76.6–88.4)	0.0 (0.0–9.7)	100.0 (93.5–100.0)

CI confidence interval, GEP gene expression profiling, NPV negative predictive value, PPV positive predictive value