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Evaluation of coagulation parameters in symptom-free periods and during attacks in the same C1-INH-HAE patients(Panels a-f). Each patient is represented by a single value, which was calculated as the mean in case several attacks had occurred. The results of the patients and those of the healthy controls were compared using the Mann–Whitney test; whereas the “symptom-free” or “during attack” results of the same patients were compared with the paired t-test
