Table 1.
The median levels of the proteins and markers of plasma enzyme systems in symptom-free periods and during attacks in the same C1-INH-HAE patients. The Linear Mixed Model was used on all measured parameters to simulate random effects and repeated measures, as well as to detect differences between the “symptom-free” and the “during-attack” states of the same patients
| Dependent variable | Estimatea | 95 % Confidence interval | P-valuea | |
|---|---|---|---|---|
| Lower limit | Upper limit | |||
| Factor XII, % | 5.657 | 5.644 | 5.671 | 0.019 |
| Factor XI, % | 4.365 | 4.350 | 4.380 | 0.118 |
| Prothrombin fragments 1 + 2, pmol/L | 387.251 | 386.257 | 388.245 | 0.001 |
| Prothrombin time, sec | −0.533 | −0.534 | −0.534 | <0.0001 |
| Activated partial thromboplastin time, sec | −3.039 | −3.041 | −3.037 | <0.0001 |
| Thrombin-anti-thrombin complex, μg/L | 4.981 | 4.971 | 4.991 | 0.004 |
| Fibrinogen, g/L | 0.414 | 0.414 | 0.414 | 0.012 |
| D-dimer, mg/L | 3.105 | 3.104 | 3.106 | <0.0001 |
| Plasminogen, % | 1.731 | 1.721 | 1.741 | 0.361 |
| Plasminogen activator inhibitor-1, U/ml | −0.524 | −0.525 | −0.525 | 0.006 |
aFor the difference between the “during attack” and the “symptom-free” samples