. 2015 Oct 9;10:132. doi: 10.1186/s13023-015-0351-5

Table 2.

Parameters of the coagulation and of the fibrinolytic system in symptom-free periods and during attacks, in the same C1-INH-HAE patients. The Linear Mixed Model was used to simulate random effects and repeated measures, to detect differences between the attacks occurring at a “Single site” vs. at “Multiple sites”, or in subcutaneous (SC) vs. submucosal (SM) location

Dependent variable	Comparison made between:	Estimate^a	95 % Confidence interval		P value^a
Dependent variable	Comparison made between:	Estimate^a	Lower bound	Upper bound	P value^a
Prothrombin time, sec	Attack at single site vs. multiple sites	−0.478	−0.590	−0.367	0.018
Prothrombin time, sec	Attack in SC or SM location	0.052	−0.004	0.109	0.816
D-dimer, mg/L	Attack at single site vs. multiple sites	3.504	2.699	4.308	0.002
D-dimer, mg/L	Attack in SC or SM location	−1.737	−1.953	−1.522	0.060
Plasminogen, %	Attack at single site vs. multiple sites	−16.619	−21.280	−11.960	0.008
Plasminogen, %	Attack in SC or SM location	10.778	8.763	12.792	0.051

^aFor the difference between the “during attack” and the “symptom-free” samples