Table 2. Follow-up of HlV-exposed infants in Kinshasa, Democratic Republic of Congo, by calendar period at infant enrollment into care and enrollment status of the mother (newly enrolled during pregnancy or previously enrolled).
| Overall | Newly Enrolled | Previously Enrolled | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||||
| 2007–2008 | 2009–2010 | 2011–2012 | 2007–2008 | 2009–2010 | 2011–2012 | 2007–2008 | 2009–2010 | 2011–2012 | |
| All HlV-exposed infants (N) | 335 | 730 | 642 | 315 | 636 | 460 | 20 | 94 | 182 |
| First specimen collection for virological HIV test | |||||||||
| Person-months of follow-up | 1435 | 1943 | 694 | 1265 | 1692 | 483 | 170 | 251 | 211 |
| N | 220 | 604 | 612 | 212 | 522 | 435 | 8 | 82 | 177 |
| 18-month cumulative incidence (95% CL) | 0.73 (0.68, 0.78) | 0.89 (0.86, 0.91) | 0.99 (0.98, 1.00) | 0.76 (0.70, 0.80) | 0.88 (0.85, 0.91) | 0.99 (0.98, 1.00) | 0.40 (0.19, 0.60) | 0.89 (0.80, 0.94) | 0.99 (0.96, 1.00) |
| Median weeks from enrollment to collection (IQR)a | 12.3 (4.9–63.1) | 4.9 (3.7–27.9) | 4.0 (1.3–4.9) | 9.9 (4.7–50.0) | 4.9 (3.7–32.7) | 4.0 (0.1–5.0) | .c (30.7-.)c | 4.7 (3.9–8.6) | 4.3 (3.7–4.9) |
| Median age in weeks at collection (IQR)b | 30.3 (8.1–.)c | 8.3 (6.7–39.3) | 7.0 (6.6–10.4) | 25.4 (8.0–71.4) | 9.0 (6.9–39.4) | 7.3 (6.6–12.3) | .c (39.3-.)c | 7.3 (6.6–12.0) | 6.9 (6.4–7.6) |
| Final outcomes | |||||||||
| Person-months of follow-up | 3425 | 6446 | 8378 | 3227 | 5459 | 5614 | 198 | 987 | 2764 |
| Confirmed HIV infection (N) | 39 | 67 | 36 | 38 | 62 | 35 | 1 | 5 | 1 |
| 18-month cumulative incidence (95% CL) | 0.15 (0.11, 0.21) | 0.12 (0.09, 0.15) | 0.08 (0.06, 0.11) | 0.16 (0.11, 0.22) | 0.13 (0.10, 0.16) | 0.11 (0.08, 0.16) | 0.05 (0.00, 0.21) | 0.06 (0.02, 0.12) | 0.01 (0.00, 0.03) |
| Death (N) | 23 | 33 | 17 | 22 | 28 | 12 | 1 | 5 | 5 |
| 18-month cumulative incidence (95% CL) | 0.08 (0.05, 0.11) | 0.05 (0.04, 0.07) | 0.03 (0.02, 0.05) | 0.08 (0.05, 0.12) | 0.05 (0.03, 0.07) | 0.03 (0.02, 0.05) | 0.05 (0.00, 0.21) | 0.06 (0.02, 0.12) | 0.03 (0.01, 0.07) |
| LTFU (N) | 59 | 103 | 111 | 59 | 97 | 96 | 0 | 9 | 15 |
| 18-month cumulative incidence (95% CL) | 0.18 (0.14, 0.22) | 0.15 (0.13, 0.18) | 0.18 (0.15, 0.21) | 0.19 (0.15, 0.23) | 0.16 (0.13, 0.19) | 0.22 (0.18, 0.26) | 0.00 (0.00, 0.00) | 0.1 (0.05, 0.17) | 0.09 (0.05, 0.14) |
| HIV-infected infants (N) | 39 | 67 | 36 | ||||||
| Person-months of follow-up | 364 | 387 | 151 | ||||||
| Died before cART (N) | 6 | 8 | 1 | ||||||
| LTFU before cART (N) | 5 | 3 | 1 | ||||||
| cART (N) | 21 | 56 | 34 | ||||||
| 24-month cumulative incidence (95% CL) | 0.61 (0.43, 0.75) | 0.88 (0.77, 0.94) | 0.97 (0.82, 1.00) | ||||||
| Median months from enrollment to cART (IQR)a | 12.1 (5.0-.)c | 4.9 (3.0–11.8) | 3.8 (1.2–6.3) | ||||||
| Median age in months at cART (IQR)b | 17.9 (10.8-.)c | 9.2 (5.1–17.2) | 9.3 (5.5–13.5) | ||||||
cART, combination antiretroviral therapy; CL, confidence limits; IQR, interquartile range; LTFU, loss to follow-up
a
Estimated from the cumulative incidence function using time since enrollment as the time scale.
b
Estimated from the cumulative incidence function using age as the time scale.
c
The cumulative incidence in this period was less than 0.5 (median) or 0.75 (upper quartile range) by the end of follow-up.