Table 2.
Cases of chronic infection
| Patient | Duration of infection | Year of acquisition | Eradication attempted | Eradication successful | Outcome |
|---|---|---|---|---|---|
| 1 (O’Carroll, 2003) [12] | >15 years | 1987 | No | N/A | Slow decline in lung health consistent with CF; transplant 2004 |
| 10 (O’Carroll, 2003) [12] | 11 years | 2001 | No | N/A | Slow decline in lung health consistent with CF |
| 3 (Schülin, 2001) [14] | >9 years | 1992 | Yes | No | Increased frequency of exacerbations |
| 15 | >8 years | 2005 | Yes | No | Accelerated decline; transplant declined due to B. pseudomallei infection; B. pseudomallei septicaemia;a died 2009 |
| 22 (Radhakrishna, 2014) [17] | 7 years | 2011 | Yes | Yes | No obvious clinical impact |
| 2 | 7 years | Early 1990’s | No | N/A | Spontaneously clearance of infection after approx. 7 years; 11 years later died of neutropenic sepsis complicating treatment of Duke’s C colon cancer. |
| 7 (Holland, 2002) [16] | >6 years | 2000 | Yes | No | Accelerated decline with increased frequency of exacerbations; B. pseudomallei septicaemia; died 2009 |
| 17 | 6 years | 2007 | No | N/A | Slow decline in lung health consistent with CF |
| 18 | 6 years | 2007 | Yes | No | Accelerated decline; transplant declined due to B. pseudomallei; died 2013 |
| 11 (Holland, 2002) [15] | 5 years | 2001 | Yes | No | Accelerated decline; transplant 2006; died 2011 |
| 23 | >12 months | 2012 | Yes | No | Progressive destruction right upper lobe |
| 6 (Holland, 2002) [16] | >4 years | 1999 | Yes | No | After presumed latency of 4 years developed accelerated decline with pneumonia; died 2004 |
| 24 | 4 years | 2009 | Yes | Unknown | Fall in lung function; stable after targeted antimicrobial therapy |
| 14 (Barth, 2007) [9] | >2 years | 2005 | Yes | No | Accelerated decline with rapid decrease in lung function and recurrent exacerbations over 2 years; long term outcome unknown |
| 8 (O’Carroll, 2003) [12] | 2 years | 2000 | Yes | No | Rapid decline post infection; died 2 years after initial infection |
| 21 | 2 years | 2010 | Yes | No | Accelerated decline; transplant 2012 with persistent infection post-transplant |
| 12 (O’Carroll, 2003) [12] | 2 years | 2001 | Yes | Yes | Repeated admissions with pneumonia, treated with 3 week courses of ceftazidime, meropenem, tobramycin; infection ultimately spontaneously cleared |
| 4 (Visca, 2001) [15] | 1 year | 1998 | Yes | Yes | Deteriorating pulmonary sepsis, increasingly refractory to anti-pseudomonal antibiotics; cleared infection with antimicrobial therapy; still alive 2013 |
| 13 (Asiah, 2006) [8] | 1 year | 2004 | Yes | Yes | Increased pulmonary sepsis during infection with B. pseudomallei; remained well 5 months after completing targeted anti-microbial therapy |
aRecurrent episodes of B. pseudomallei bacteremia
bIn patient 5 the duration of infection and long term outcome was unknown