. 2015 Sep 23;3(9):e12559. doi: 10.14814/phy2.12559

Table 1.

Action potential parameter response to hydrogen peroxide

	APD₉₀ (msec)	APD₅₀ (msec)	dV/dt (mV/msec)	V_r (mV)
Dct-null CMCLs
Baseline (n = 12)	56.9 ± 7.2^*^†^¶	24.8 ± 8.1^*^†^¶	34.8 ± 9.2	–68.4 ± 6.0
5 μmol/L H₂O₂ (n = 12)	59.0 ± 8.5^*^†^¶	25.2 ± 7.1^*^†^¶	34.2 ± 8.9	–68.1 ± 6.7
10 μmol/L H₂O₂ (n = 12)	71.5 ± 13.8^*^†^¶	30.2 ± 8.6^*^†^¶	33.7 ± 9.2	–67.7 ± 7.2
25 μmol/L H₂O₂ (n = 12)	78.3 ± 12.6^*^†^¶	33.0 ± 9.1^*^†^¶	34.1 ± 9.6	–67.5 ± 6.9
50 μmol/L H₂O₂ (n = 12)	80.4 ± 11.9^*^†^¶	34.2 ± 7.4^*^†^¶	33.9 ± 9.4	–67.4 ± 7.1
Dct-het. melanocytes
Baseline (n = 12)	32.2 ± 1.5^‡	14.3 ± 1.8^‡	34.9 ± 9.0	–68.5 ± 7.0
5 μmol/L H₂O₂ (n = 12)	34.1 ± 1.3^‡	14.9 ± 1.4^‡	34.6 ± 8.8	–68.0 ± 6.1
10 μmol/L H₂O₂ (n = 12)	36.8 ± 1.7^†^‡^¶	16.6 ± 1.6^‡	34.2 ± 9.4	–67.8 ± 6.8
25 μmol/L H₂O₂ (n = 12)	45.2 ± 2.8^†^‡^¶	19.2 ± 2.4^‡	34.5 ± 9.6	–67.2 ± 7.0
50 μmol/L H₂O₂ (n = 12)	49.3 ± 3.1^†^‡^¶	20.1 ± 3.2^‡	33.8 ± 9.2	–67.3 ± 7.1
Dct-null CMCLs
Baseline (n = 11)	31.3 ± 1.5^‡	13.1 ± 1.7^‡	36.8 ± 9.8	–68.6 ± 7.2
5 μmol/L H₂O₂ (n = 11)	32.0 ± 1.7^‡	13.3 ± 1.8^‡	36.4 ± 10.0	–68.0 ± 7.1
10 μmol/L H₂O₂ (n = 11)	32.6 ± 1.9^*^‡	14.9 ± 1.5^‡	36.3 ± 8.7	–67.7 ± 6.7
25 μmol/L H₂O₂ (n = 11)	37.3 ± 2.0^‡	18.2 ± 2.3^‡	36.8 ± 8.8	–67.4 ± 7.3
50 μmol/L H₂O₂ (n = 11)	42.4 ± 3.1^‡	19.0 ± 3.8^‡	35.2 ± 9.3	–67.1 ± 6.8
Dct-het myocytes
Baseline (n = 11)	30.9 ± 1.8^‡	12.8 ± 2.0^‡	37.1 ± 8.9	–68.3 ± 6.7
5 μmol/L H₂O₂ (n = 11)	31.7 ± 2.0^‡	13.0 ± 2.1^‡	36.9 ± 9.3	–68.5 ± 6.9
10 μmol/L H₂O₂ (n = 11)	32.3 ± 2.2^*^‡	14.4 ± 1.9^‡	36.8 ± 8.8	–68.2 ± 6.4
25 μmol/L H₂O₂ (n = 11)	37.0 ± 2.5^‡	17.6 ± 2.5^‡	37.2 ± 9.2	–67.9 ± 7.0
50 μmol/L H₂O₂ (n = 11)	41.9 ± 2.9^‡	18.8 ± 3.6^‡	36.6 ± 9.0	–67.4 ± 7.3

P < 0.05 compared to Dct-het. CMCLs at same H₂O₂ concentration.

^†

P < 0.05 compared to Dct-het. atrial myocytes at same H₂O₂ concentration.

^‡

P < 0.05 compared to Dct-null CMLCs at same H₂O₂ concentration.

^¶

P < 0.05 compared to Dct-null atrial myocytes at same H₂O₂ concentration.