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. 2015 Apr 10;21(2):469–480. doi: 10.1111/adb.12245

Table 1.

Association of AD polygenic risk with alcohol consumption, education and SIMD. All associations are adjusted for age, sex and four MDS components to adjust for population stratification. Covariate adjusted models are presented with the inclusion of the other traits as covariates, e.g. alcohol consumption is adjusted for education and SIMD

Trait SAGE AD polygenic risk score SAGE AD polygenic risk score + covariates SAGE AD polygenic risk score SAGE AD polygenic risk score + covariates Meta‐analysis AD polygenic risk score Meta‐analysis AD polygenic risk score + covariates
Stats P Stats P Stats P Stats P Stats P Stats P
Alcohol consumption β = 0.035, r 2 = 0.001 0.0007 β = 0.045, r 2 = 0.0019 0.00003 β = 0.04, r 2 = 0.0014 0.00012 β = 0.042, r 2 = 0.0017 0.00009 β = 0.049, r 2 = 0.002 2.8 × 10−6 β = 0.056, r 2 = 0.003 2.1 × 10−7
Education β = −0.055, r 2 = 0.0028 2.6 × 10−7 β  = −0.043, r 2 = 0.0016 0.00006 β = −0.033, r 2 = 0.0009 0.0021 β = −0.022, r 2 = 0.0003 0.035 β = −0.049, r 2 = 0.0021 5.4 × 10−6 β = 0.035, r 2 = 0.001 0.001
SIMD β = −0.054, r 2 = 0.0028 5.2 × 10−7 β = −0.044, r 2 = 0.0018 0.00005 β = −0.047, r 2 = 0.002 0.000012 β = −0.046, r 2 = 0.0018 0.00003 β = −0.063, r 2 = 0.004 1.1 × 10−8 β = 0.056, r 2 = 0.003 2.6 × 10−7

P‐values highlighted in bold remain significant after FDR correction for multiple comparisons. Polygenic risk scores derived from SNPs with a GWAS P‐value ≤ 0.5 are presented.