Table 1.

Association of AD polygenic risk with alcohol consumption, education and SIMD. All associations are adjusted for age, sex and four MDS components to adjust for population stratification. Covariate adjusted models are presented with the inclusion of the other traits as covariates, e.g. alcohol consumption is adjusted for education and SIMD

Trait	SAGE AD polygenic risk score		SAGE AD polygenic risk score + covariates		SAGE AD polygenic risk score		SAGE AD polygenic risk score + covariates		Meta‐analysis AD polygenic risk score		Meta‐analysis AD polygenic risk score + covariates
	Stats	P	Stats	P	Stats	P	Stats	P	Stats	P	Stats	P
Alcohol consumption	β = 0.035, r 2 = 0.001	0.0007	β = 0.045, r 2 = 0.0019	0.00003	β = 0.04, r 2 = 0.0014	0.00012	β = 0.042, r 2 = 0.0017	0.00009	β = 0.049, r 2 = 0.002	2.8 × 10−6	β = 0.056, r 2 = 0.003	2.1 × 10−7
Education	β = −0.055, r 2 = 0.0028	2.6 × 10−7	β  = −0.043, r 2 = 0.0016	0.00006	β = −0.033, r 2 = 0.0009	0.0021	β = −0.022, r 2 = 0.0003	0.035	β = −0.049, r 2 = 0.0021	5.4 × 10−6	β = 0.035, r 2 = 0.001	0.001
SIMD	β = −0.054, r 2 = 0.0028	5.2 × 10−7	β = −0.044, r 2 = 0.0018	0.00005	β = −0.047, r 2 = 0.002	0.000012	β = −0.046, r 2 = 0.0018	0.00003	β = −0.063, r 2 = 0.004	1.1 × 10−8	β = 0.056, r 2 = 0.003	2.6 × 10−7

P‐values highlighted in bold remain significant after FDR correction for multiple comparisons. Polygenic risk scores derived from SNPs with a GWAS P‐value ≤ 0.5 are presented.