Table 3.
Association of the interaction term SIMD*polygenic risk score with cognitive variables previously shown to be associated with polygenic risk for alcohol dependence
| Polygenic risk score | Verbal fluency | Mill Hill vocabulary | Digit symbol coding | |||
|---|---|---|---|---|---|---|
| Beta (SE) | P‐value | Beta (SE) | P‐value | Beta (SE) | P‐value | |
| SAGE score * SIMD | −0.0003 (0.01) | 0.98 | 0.026 (0.01) | 0.01 | 0.019 (0.009) | 0.04 |
| Yale‐Penn * SIMD | −0.0035 (0.01) | 0.75 | 0.024 (0.01) | 0.02 | 0.016 (0.009) | 0.09 |
| Meta‐analysis * SIMD | −0.0018 (0.01) | 0.87 | 0.031 (0.01) | 0.004 | 0.023 (0.009) | 0.01 |
Results shown are corrected for age, sex, four MDS components; and SIMD and polygenic risk score are included as main effects. Polygenic risk scores derived from SNPs with a GWAS P‐value ≤ 0.5 are presented. Bold highlighted P‐value is significant after FDR correction.