Table 4.
Summary of changes in immunologic parameters for active compared to placebo groups.
| Group | Baseline Visit Mean (SD) | Last Visit Mean (SD) | Baseline/Site Adjusted Difference | P-value for Diff=0 | Diff between Differences [95% CI] p-value | |
|---|---|---|---|---|---|---|
| Food Specific IgE | A (n=27) | 23.80 (24.39) | 30.55 (30.59) | 6.63 | 0.0662 | 3.67 [-7.54, 14.89] P=0.51 |
| P (n=15) | 20.16 (25.46) | 24.45 (29.50) | 2.96 | 0.5418 | ||
| Food Specific IgG4 | A (n=25) | 1.13 (1.44) | 1.20 (1.67) | 0.06 | 0.7559 | 0.28 [-0.34, 0.91] P=0.37 |
| P (n=14) | 1.32 (2.06) | 1.08 (1.80) | -0.22 | 0.3731 | ||
| Food Specific IgE/IgG4 Ratio | A (n=16) | 117.91 (227.01) | 84.29 (105.67) | -27.25 | 0.4944 | -52.66 [-183.67, 78.35] P=0.41 |
| P (n=10) | 93.19 (223.95) | 128.80 (242.98) | 25.41 | 0.6137 | ||
| IL5 -Allergen | A (n=30) | 342.46 (598.34) | 565.01 (554.51) | 211.64 | 0.0476 | 318.72 [3.75, 633.69] P=0.05 |
| P (n=18) | 211.40 (438.91) | 238.42 (285.18) | -107.08 | 0.4480 | ||
| IL10 – Allergen | A (n=32) | 68.53 (129.28) | 92.11 (192.53) | 4.64 | 0.8723 | 34.15 [-54.43, 122.74] P=0.44 |
| P (n=18) | 200.91 (521.89) | 115.92 (172.04) | -29.51 | 0.4467 | ||
| IFN – γ Allergen | A (n=32) | 156.13 (263.92) | 196.92 (323.94) | 78.65 | 0.1571 | -110.00 [-281.31, 61.30] P=0.20 |
| P (n=17) | 151.23 (230.93) | 228.35 (371.57) | 188.66 | 0.0161 |