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. Author manuscript; available in PMC: 2016 Oct 1.

Published in final edited form as: J Allergy Clin Immunol. 2015 Jul 26;136(4):874–884. doi: 10.1016/j.jaci.2015.05.044

A. Heatmap of the ten taxa found significantly enriched among severe asthmatics (n=30) compared to healthy controls (n=7) (Benjamini-Hochberg p_adj < 0.15; R package limma)

B. Heatmap of the 95 total taxa found to significantly differ in relative abundance between severe asthma (n=30) and mild-moderate asthma subjects (n=41) (≥ 2-fold-difference; Benjamini-Hochberg p_adj < 0.01; R package limma). Relative to the other group, severe asthmatics were enriched in 53 taxa, while mild-moderate asthmatics were conversely enriched in 42 taxa.

A. Heatmap of the ten taxa found significantly enriched among severe asthmatics (n=30) compared to healthy controls (n=7) (Benjamini-Hochberg p_adj < 0.15; R package limma)

B. Heatmap of the 95 total taxa found to significantly differ in relative abundance between severe asthma (n=30) and mild-moderate asthma subjects (n=41) (≥ 2-fold-difference; Benjamini-Hochberg p_adj < 0.01; R package limma). Relative to the other group, severe asthmatics were enriched in 53 taxa, while mild-moderate asthmatics were conversely enriched in 42 taxa.