Fig. 7.

Dose dependent blockade of [¹⁸F]ASEM (0.07 mCi, specific radioactivity = 7900 mCi/μmol, i.v.) accumulation by intravenous co-injection of SSR180711, a selective α7-nAChR partial agonist (doses 0.02 mg/kg, 0.2 mg/kg, 1 mg/kg, 3 mg/kg) in the CD-1 mouse brain regions 90 min after the injection. *P ≤ 0.01, significantly different from controls (ANOVA). Data: mean %injected dose/g tissue ± SD (n=3). Abbreviations: Coll = superior and inferior colliculus; Hipp = hippocampus; Ctx = cortex; Str = striatum; Th = thalamus; Rest = rest of brain; CB = cerebellum. Reprinted from [48] with permission of Copyright Clearance Center's RightsLink service