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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: Biochem Pharmacol. 2015 Jul 29;97(4):566–575. doi: 10.1016/j.bcp.2015.07.030

Table 2.

Comparison of in vitro α7-nAChR inhibition binding affinities of ASEM versus previous PET radioligands NS14492, NS10743, AZ11637326.

Compound Ki, nM a[48]
NS14492 20.4
NS10743 38.0
AZ11637326 3.3
ASEM 0.37, 0.45
a

The binding assay performed under the same conditions: rat cortical membranes, radiotracer [125I]α-bungarotoxin (0.1 nM), KD = 0.7 nM (commercial assay, CEREP, www.cerep.fr).