Fig. 2.

Study design. Rats were kept on a Light (L) phase–Dark (D) phase 12:12 cycle (8.00 a.m–8.00 p.m.). For baseline data, rats underwent simple response latency testing at Circadian Time (CT) 3–5 on “Pre” day. On “Test” day sleep deprivation commenced at onset of Light Phase and was continued for 11 h (CT0-CT11). All drugs were dosed at CT10.5 (10.5 h after lights on). At CT11 animals were removed from sleep deprivation wheels and placed immediately into operant boxes for a 40-min SRLT session. Rats were then retested in the SRLT on “Post” day between CT 3–5